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Colloquially, wisdom is an acquired awareness of what matters most in situations, a defense against illusion.
MIT neuroscientist Matt Wilson (via Maria Popova):
Wisdom is the rules, based on experience, that allows us to make good decisions in novel situations in the future.
Wisdom is awareness of one’s ignorance
In 426 BCE, the oracle at Delphi proclaimed Socrates the wisest person alive for knowing that he knows nothing. In the words of Diogenes Laërtius, “he knew nothing except just the fact of his ignorance.”